Pharmacogenomics is the science that studies how an individual’s genetic makeup influences the way they respond to medication.
Pharmacogenomic testing is now offered to patients who are experiencing unwanted side effects of their medication or are experiencing medication failure. In fact, pharmacogenomic testing is being performed on individuals prior to a medication being prescribed, thereby providing valuable insights about their genetics, which will assist their doctors to select the most appropriate, effective, and tolerable medication for their patient.
We all have genes that control the metabolism of many commonly prescribed medications. Some help the process of clearing the medication from our bodies, while others activate a drug once taken, making it available in the correct form to perform its desired function.
Over 98% of us have a gene variant that may impact a medication response, with 79% having three or more variants.
As such, we are all genetically predetermined to be either normal, poor, or rapid metabolisers when it comes to specific medications. Other genes are responsible for carrying medications throughout the body and indeed, into the brain. Naturally, variants in these genes will also impact on how we respond to medications.
Knowing your metabolism status or your pharmacogenomic status is of real value whether you are currently taking medications or will take medications sometime in the future, as one pharmacogenomic test can provide guidance to over 170 medications that are prescribed in oncology, psychiatry, cardiology, pain management, general practice, gastroenterology, rheumatology and even in the treatment of infectious disease.
Incite Genomics offer a variety of pharmacogenomic tests that will suit any patient, particularly if you are experiencing difficulties with some of the example medications below.
|Antidepressants (eg Citalopram, Sertraline, Tricyclics, Venlafaxine)|
|Anticoagulant/Antiplatelet (eg Warfarin, Clopidogrel)|
|Pain Medication (eg Codeine, Tramadol)|
|Statin (eg Simvastatin, Rosuvastatin)|
|Proton Pump Inhibitor (eg Esomeprazole)|
|Antifungal Agent (eg Voriconazole)|
|Chemotherapy (eg 5-Fluorouracil)|
For further information contact us today.